Biphasic effects of intraaccumbens mu-opioid peptide agonist DAMGO on locomotor activities

The effects of bilateral microinjections of mu-opioid receptor agonist DAMGO (0.00, 0.01, 0.1, or 1.0 microgram/side) were tested in rats for 120 min in activity monitors. The horizontal movement, rearing, and stereotypy times in seconds were measured during 12 consecutive 10-min time blocks. DAMGO (0.01, 0.1, and 1.0 microgram) resulted in biphasic effects, inhibition followed by activation for each of the three measures. These data replicate the behavioral effects of ICV DAMGO except that the duration of the behavioral effects were longer with Acb injections.     

Cyclosporin A and cyclosporin SDZ PSC 833 enhance anti-CD5 ricin A-chain immunotoxins in human leukemic T cells

Recent studies have shown that cyclosporin A (CsA) may affect ricin A-chain immunotoxin (RTA-IT) therapy. In this study, we evaluated the ability of CsA and its nonimmunosuppressive analog, SDZ PSC 833, to enhance anti-CD5 T101 RTA-ITs in vitro. Both 4 mumol/L CsA and 4 mumol/L SDZ PSC 833 significantly and specifically enhanced the cytotoxic activity of T101 RTA-IT on the human lymphoblastic T-cell line, CEM III (101-fold and 105-fold, respectively). Furthermore, these Cs also enhanced the cytotoxicity of the more potent T101 F(ab')2 RTA-IT (ninefold and eightfold, respectively). The effect of human plasma, originating from four patients enrolled in a phase I high-dose CsA regimen, was examined on T101 RTA-IT cytotoxicity on CEM III cells. In each case, with plasma CsA levels between 3,090 and 4,860 ng/mL (2.5 to 4 mumol/L), a significant increase in T101 RTA-IT-mediated cytotoxicity was observed ranging from 31% to 60%. Neither CsA nor SDZ PSC 833 affected the rate of RTA-IT binding, internalization, intracellular trafficking, or degradation. Analysis of internalized T101 RTA-IT molecules showed that these were essentially intact, which suggests that these enhancers may act only on a small population of RTA-ITs that escapes present investigational techniques. In conclusion, because the concentrations used are clinically achievable, Cs appear to be promising agents for in vivo enhancement of RTA-ITs.     

高功率DPL光束质量研究

为了在高功率DPL中获取高光束质量输出激光，利用扭转模获取高光束质量种籽源的同时，进行了高重复频率下的热致及光致双折射效应的补偿、高功率二极管均匀泵浦聚光腔设计及相位共轭镜用于改善激光系统光束质量等特性研究。最终获得了重复频率40Hz、单脉冲能量大于400mJ、近衍射极限的高光束质量激光输出。这种方法对高功率激光系统的设计十分有用。     

尖晶石型纳米钴蓝陶瓷颜料的制备

采用化学共沉淀法作为钴蓝颜料的制备方法,探讨了主要工艺因素对制备钴蓝颜料性能的影响,对制备的样品进行了测试与表征。结果表明:Co2+和Al3+物质的量比为1∶2.5时,制备的钴蓝样品颜色饱和度与明度最高,沉淀剂为尿素时制得的样品的粒度最小,粒度分布比较均匀。前驱体的洗涤过程采取水洗加醇洗的方法可有效减少样品的硬团聚现象,且前驱体的最佳煅烧温度为950℃左右。     

Hilar cholangiocarcinoma: thin-section spiral CT findings with cholangiographic correlation

Hilar cholangiocarcinoma, a highly lethal tumor, is difficult to diagnose with conventional computed tomography (CT) because of its small size. Spiral CT allows more effective evaluation of these small lesions and better demonstrates the status of the hepatic arterial or portal venous circulation. Among 27 patients with hilar cholangiocarcinoma (infiltrative in 21, exophytic in two, polypoid in one, diffuse in three), thin-section spiral CT allowed identification of each tumor as an area of focal wall thickening that obliterated the lumen. Seventeen of the infiltrative tumors (81%) showed high attenuation. Identification of the level of biliary obstruction was possible in 63% of the patients (17 of 27). The level of obstruction was underestimated in six patients and overestimated in four. Spiral CT is a valuable method for diagnosis of hilar cholangiocarcinoma; however, spiral CT is less accurate in evaluation of intraductal tumor extent because of the limited z-axis resolution.     

窄带中频数字接收机高速信号处理技术

窄带中频数字接收机在雷达对抗侦察中得到了广泛应用，其高速信号处理技术是目前研究的重点。本文详细介绍了数字雷达告警接收机高速信号处理技术的发展现状和关键技术，最后通过对该技术的全面分析指出了值得深入研究的领域。     

计及PMU的混合非线性状态估计新方法

提出一种将同步相量测量单元（PMU）的直接电压相量量测变换为间接支路电流量测，并与监控与数据采集（SCADA）量测量一起进行混合迭代的非线性状态估计方法。对构造等效电流修正量而带来的间接量测误差进行了详细和定量的分析，并对该混合估计算法的精度进行了定性分析和定量计算。理论分析和算例表明，该方法可以获得较高的估计精度，在收敛次数和滤波效果上也有所改进。     

火电机组运行优化系统的现状与展望

简单回顾了国内外在火电机组运行优化领域的研究历程，列举了目前国内外市场上针对火电机组的各种主流运行优化产品的功能特点和应用情况，分析了国外引进产品和国内自主研发产品在中国当前市场环境下各自的优势和劣势。介绍了当前运行优化系统在国内电站机组的应用现状，阐述了国内外运行优化系统在实际应用中存在的问题，并提出了相应的改进意见。对机组运行优化系统的未来发展进行了展望，指出机组运行优化系统将利用先进技术设备和信息平台，与电站管理紧密结合，在日益规范的市场中不断发展完善，为提高电站经济性发挥更大的作用。     

分离纯化低聚异麦芽糖的酵母菌菌株筛选

对山东寿光市保护地蔬菜施肥状况的调查及产生的问题综合评价表明 :寿光市保护地蔬菜施肥用量很大 ,但极不平衡 ,化学氮肥及磷肥施用量过大造成了土壤的盐化、酸化、中微量元素的缺乏及环境的污染 ,使得蔬菜的产品品质下降 ,蔬菜NO-3 含量较高 ,产投比降低。钾肥用量太少 ,植物抗逆性差 ,病虫害严重。提出了蔬菜合理施肥的几项建议。